Adjuvant for chitosan-based gel solution with minimal stress
The microparticle adjuvantis a chitosan-based adjuvant with great bioavailability, and biodegradation with nearly no toxicity. Chitosan itself is a strong immunostimulant with its carbohydrate polysaccharides branches. The antigen can be encapsulated by chitosan through forming an electrostatic interaction from the positive charged chitosan to the negatively charged antigen. The encapsulated complex can then form into a microparticle dispersed in the aqueous phase as a prepared vaccine.